What Is Esketamine Nasal Spray? Fast-Acting Depression Relief in Sacramento at ZenKetamine

For individuals with treatment-resistant depression (TRD), esketamine nasal spray offers hope. This innovative therapy delivers rapid relief, even when other treatments have failed. At Zen Ketamine in Sacramento, we specialize in esketamine treatments, providing safe and effective care for those seeking a brighter future.

 
Understanding Esketamine Nasal Spray

What Is Esketamine (Spravato)?

Esketamine is one of the two mirror-image molecules that make up ketamine, a medication originally used as an anesthetic. Its potential as a powerful antidepressant was discovered in the early 2000s.

In 2010, Janssen Pharmaceuticals, part of Johnson & Johnson, developed Spravato, an intranasal version of esketamine to treat depression. Esketamine interacts more strongly with NMDA receptors (see more below), so it is believed to have a more targeted effect in depression treatment. 

In 2019, the FDA approved Spravato, the intranasal version of esketamine, for treating TRD and major depressive disorder with suicidal ideation (MDSI). With over 60,000 U.S. patients treated, esketamine has transformed depression care by offering a more targeted and effective approach.

 
How Does Esketamine Work in the Brain?

Esketamine blocks NMDA receptors, initiating cellular reactions that increase neuroplasticity—the brain’s ability to form new neural connections. As shown in studies, this mechanism helps “re-wire” dysfunctional circuits linked to depression and improves brain regions responsible for mood regulation and stress response.

Esketamine also boosts brain-derived neurotrophic factor (BDNF), a molecule essential for nerve cell growth and repair. This may aid in reversing the loss of brain tissue often observed in individuals with chronic depression.

 
Esketamine vs. Ketamine

While both esketamine and ketamine target NMDA receptors, esketamine binds more selectively, allowing for lower doses and potentially fewer side effects. Unlike ketamine, which is often used “off-label,” esketamine is FDA-approved, meaning insurance plans typically cover its costs. Patients may pay as little as a standard co-pay for treatment at Zen Ketamine in Sacramento.

 
Benefits of Esketamine for Depression Relief

1. Hope for When Other Treatments Fail

Esketamine is a game-changer for those with TRD. In a study involving nearly 300 patients, more than half achieved remission when esketamine was paired with an antidepressant.

2. Rapid Action

Unlike traditional antidepressants that take weeks to work, esketamine provides significant mood improvements within hours or days, offering quick relief for those in crisis.

3. Long-Lasting Results

Esketamine’s effects last several days after a single dose. With continued treatment, benefits can extend over months, reducing the need for daily medication and minimizing the risk of tolerance. 

In a large phase 3 study, people with TRD had significantly reduced symptoms after the first month of esketamine treatment, given twice a week. With more spaced-out regular doses thereafter, this improvement lasted for 42 weeks.

4. Alleviation of Suicidal Ideation

Esketamine is specifically approved for MDSI, providing life-saving relief to those with suicidal thoughts. Studies show a significant reduction in suicidal ideation within 24 hours of treatment.

5. FDA Approval and Safety

Esketamine has undergone rigorous testing in clinical trials, ensuring its safety and efficacy. FDA approval makes it a trusted and accessible treatment option.

 
Safety of Esketamine

Esketamine is generally well-tolerated, but like any medication, it may cause side effects.

Common Physical Side Effects:

• Dizziness or nausea
• Temporary increases in blood pressure
• Fatigue or drowsiness
  

Common Psychological Side Effects:

• Dissociation (feeling detached from reality)
• Mild hallucinations or perception changes
• Esketamine treatments are always administered under medical supervision to ensure safety and address side effects promptly.

Long-term studies suggest that esketamine is not associated with significant risks like withdrawal symptoms or drug abuse when used as prescribed. However, there is still limited data on its long-term effects, particularly with repeated use over extended periods. 

Patients are monitored during and after each session, and regular follow-ups are encouraged to ensure optimal outcomes.

 
Why Choose Zen Ketamine in Sacramento?

Assured Safety

As a certified REMS (Risk Evaluation and Mitigation Strategy) clinic, Zen Ketamine meets the highest safety standards. Our skilled professionals provide thorough monitoring during every treatment.

Trauma-Informed Care

We understand the challenges of TRD and MDSI. Our compassionate staff offers holistic, patient-centered care to support emotional well-being beyond the symptoms.

Enhanced Experience

Relax in a soothing environment with eye masks, curated playlists, and private treatment suites designed to maximize comfort and promote healing.

Affordable Options

With in-network insurance coverage, esketamine treatments may cost as little as $10 per session. We aim to make life-changing care accessible to everyone.

 
Get in Touch

If you’re ready to explore the benefits of esketamine nasal spray, schedule a consultation with Zen Ketamine in Sacramento. Our team is here to guide you through this innovative treatment and help you reclaim your life.

 
Key Takeaways

• Esketamine is FDA-approved for treatment-resistant depression and MDSI, offering a safe and trusted option for rapid relief.
• It provides fast and long-lasting results, helping stabilize mood within hours and maintaining improvement with regular sessions.
• Esketamine enhances brain neuroplasticity, potentially reversing the effects of depression on brain health.
• At Zen Ketamine in Sacramento, we prioritize safety, comfort, and affordability in our patient-centered care approach.